Lung Disease - Pulmonary fibrosis

Product Details:

Exporter and dropshipper. With track of the recent developments in the pharmaceutical industry, we are presenting a qualitative assortment of Pirfenex Tablet. Formulation of this tablet is carried out by our adroit professionals that posses enormous experience in their concerned field. To promise its high quality and purity, offered tablet is tested on varied quality parameters. Clients can avail this tablet in different specifications as per their varied requirements.

Features:

• High medicinal value
• Correct formulation
• Safely packed Form Packing 

Additional Information:

• Delivery Time: 8 Days

Product Details:

This product is always available in stock, we do shipping in any country worldwide.

All the custom formalities, customs clearing & shipping is done by our side. 
For large orders, prices will be negotiable. 
Estimated delivery between 6 - 8 Days. 

 

Description:

• Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by InterMune.

 

Mechanism of Action:

• Pirfenidone is an orally active, small molecule that shows a wide range of biologic activity. In vitro evidence has shown that pirfenidone inhibits collagen synthesis, down-regulates profibrotic cytokines and decreases fibroblast proliferation. Pirfenidone leads to a reduction of TGF-beta2 mRNA levels and of the mature TGF-beta2 protein due to decreased expression and direct inhibition of the TGF-beta pro-protein convertase furin. In addition, pirfenidone reduces the protein levels of the matrix metalloproteinase (MMP)-11, a TGF-beta target gene and furin substrate involved in carcinogenesis. 

Product Details:

This product is always available in stock, we do shipping in any country worldwide.

All the custom formalities, customs clearing and shipping is done by our side.
For large orders, prices will be negotiable.
Estimated delivery between 6 - 8 Days.

 

Description:

• Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by Inter Mune.

 

Mechanism of action:

• Pirfenidone is an orally active, small molecule that shows a wide range of biologic activity. In vitro evidence has shown that pirfenidone inhibits collagen synthesis, down-regulates profibrotic cytokines and decreases fibroblast proliferation. Pirfenidone leads to a reduction of TGF-beta2 mRNA levels and of the mature TGF-beta2 protein due to decreased expression and direct inhibition of the TGF-beta pro-protein convertase furin. In addition, pirfenidone reduces the protein levels of the matrix metalloproteinase (MMP)-11, a TGF-beta target gene and furin substrate involved in carcinogenesis.